| Unique identifier for interactor A | uniprotkb:P49736 |
| Unique identifier for interactor B | uniprotkb:P33991 |
| Alternative identifier for interactor A | intact:EBI-374819 uniprotkb:Q14577 uniprotkb:Q15023 uniprotkb:Q8N2V1 uniprotkb:Q969W7 uniprotkb:Q96AE1 uniprotkb:Q9BRM7 ensembl:ENSP00000265056.7 |
| Alternative identifier for interactor B | intact:EBI-374938 uniprotkb:Q8NEH1 uniprotkb:Q99658 ensembl:ENSP00000262105.2 ensembl:ENSP00000496964.1 |
| Aliases for A | psi-mi:mcm2_human(display_long) uniprotkb:MCM2(gene name) psi-mi:MCM2(display_short) uniprotkb:BM28(gene name synonym) uniprotkb:CDCL1(gene name synonym) uniprotkb:KIAA0030(gene name synonym) uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym) uniprotkb:Nuclear protein BM28(gene name synonym) uniprotkb:CCNL1(gene name synonym) |
| Aliases for B | psi-mi:mcm4_human(display_long) uniprotkb:MCM4(gene name) psi-mi:MCM4(display_short) uniprotkb:CDC21(gene name synonym) uniprotkb:CDC21 homolog(gene name synonym) uniprotkb:P1-CDC21(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0029"(cosedimentation through density gradient) |
| First author | Nguyen et al. (2012) |
| Identifier of the publication | pubmed:22540012 imex:IM-21408 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0914"(association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-8756387 imex:IM-21408-17 |
| Confidence score | intact-miscore:0.83 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f4 comment:"\"In a reaction mixture (100 μl), the purified MCM2-7 complex (2.8 pmol as a hexamer) was mixed with purified MCM-BP (18 pmol as a monomer). After incubation for 3 h at 4°C, the mixture was separated by glycerol gradient centrifugation (middle). MCM2-7 proteins were mainly detected in fraction no. 7-9, suggesting that MCM complexes smaller than the MCM2-7 hexamer were formed. They probably included the MCM2/4/6/7 tetramer. In this reaction, MCM-BP was sedimented more quickly than the purified MCM-BP (bottom), suggesting that some MCM-BP binds to MCM2-7 proteins. These results indicate that MCM-BP disassembles the MCM2-7 hexamer to generate smaller MCM complexes.\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2013/09/09 |
| Update date | 2024/11/22 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |