| Unique identifier for interactor A | uniprotkb:P37840 |
| Unique identifier for interactor B | uniprotkb:P37840 |
| Alternative identifier for interactor A | intact:EBI-985879 uniprotkb:A8K2A4 ensembl:ENSP00000338345.3 ensembl:ENSP00000378437.1 ensembl:ENSP00000378442.4 ensembl:ENSP00000422238.1 ensembl:ENSP00000426955.1 ensembl:ENSP00000500990.1 uniprotkb:Q13701 uniprotkb:Q4JHI3 uniprotkb:Q6IAU6 |
| Alternative identifier for interactor B | intact:EBI-985879 uniprotkb:A8K2A4 ensembl:ENSP00000338345.3 ensembl:ENSP00000378437.1 ensembl:ENSP00000378442.4 ensembl:ENSP00000422238.1 ensembl:ENSP00000426955.1 ensembl:ENSP00000500990.1 uniprotkb:Q13701 uniprotkb:Q4JHI3 uniprotkb:Q6IAU6 |
| Aliases for A | psi-mi:syua_human(display_long) uniprotkb:Non-A beta component of AD amyloid(gene name synonym) uniprotkb:Non-A4 component of amyloid precursor(gene name synonym) uniprotkb:SNCA(gene name) psi-mi:SNCA(display_short) uniprotkb:NACP(gene name synonym) uniprotkb:PARK1(gene name synonym) |
| Aliases for B | psi-mi:syua_human(display_long) uniprotkb:Non-A beta component of AD amyloid(gene name synonym) uniprotkb:Non-A4 component of amyloid precursor(gene name synonym) uniprotkb:SNCA(gene name) psi-mi:SNCA(display_short) uniprotkb:NACP(gene name synonym) uniprotkb:PARK1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0943"(detection by mass spectrometry) |
| First author | Coelho-Cerqueira et al. (2013) |
| Identifier of the publication | imex:IM-21008 pubmed:23927048 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-6914913 imex:IM-21008-4 |
| Confidence score | intact-miscore:0.99 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f2c comment:"\"Mass spectrometry (MALDI-TOF/TOF) was used to confirm the oligomeric state of cross-linked α-syn. A molecular mass of 14,458 Da was obtained from the MALDI-TOF/TOF spectrum of non-cross-linked α-syn purified using the heating protocol (Figure 2C), and no differences were observed in comparison with α- syn purified using the acidification protocol (data not shown). After cross-linking, both heat- and acid-purified α-syn exhibited a minor population of dimers and trimers with the predominant monomer. For the α-syn purified using the heating protocol, a very small population of tetramers (64,269 Da) was also observed. Together, the analysis of crosslinked α-syn by both SDS-PAGE and mass spectroscopy indicated that the protein is mostly monomeric with a small population of oligomers, notably dimers.\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2013/08/04 |
| Update date | 2019/02/08 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | 2 |
| Stoichiometry for interactor B | 0 |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Predetermined participant |