| Unique identifier for interactor A | uniprotkb:P37840 |
| Unique identifier for interactor B | uniprotkb:P37840 |
| Alternative identifier for interactor A | intact:EBI-985879 uniprotkb:A8K2A4 ensembl:ENSP00000338345.3 ensembl:ENSP00000378437.1 ensembl:ENSP00000378442.4 ensembl:ENSP00000422238.1 ensembl:ENSP00000426955.1 ensembl:ENSP00000500990.1 uniprotkb:Q13701 uniprotkb:Q4JHI3 uniprotkb:Q6IAU6 |
| Alternative identifier for interactor B | intact:EBI-985879 uniprotkb:A8K2A4 ensembl:ENSP00000338345.3 ensembl:ENSP00000378437.1 ensembl:ENSP00000378442.4 ensembl:ENSP00000422238.1 ensembl:ENSP00000426955.1 ensembl:ENSP00000500990.1 uniprotkb:Q13701 uniprotkb:Q4JHI3 uniprotkb:Q6IAU6 |
| Aliases for A | psi-mi:syua_human(display_long) uniprotkb:Non-A beta component of AD amyloid(gene name synonym) uniprotkb:Non-A4 component of amyloid precursor(gene name synonym) uniprotkb:SNCA(gene name) psi-mi:SNCA(display_short) uniprotkb:NACP(gene name synonym) uniprotkb:PARK1(gene name synonym) |
| Aliases for B | psi-mi:syua_human(display_long) uniprotkb:Non-A beta component of AD amyloid(gene name synonym) uniprotkb:Non-A4 component of amyloid precursor(gene name synonym) uniprotkb:SNCA(gene name) psi-mi:SNCA(display_short) uniprotkb:NACP(gene name synonym) uniprotkb:PARK1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0030"(cross-linking study) |
| First author | Coelho-Cerqueira et al. (2013) |
| Identifier of the publication | imex:IM-21008 pubmed:23927048 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-6914889 imex:IM-21008-2 |
| Confidence score | intact-miscore:0.99 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f2a f2b f3g f4a comment:"\"To determine the oligomeric state of the recombinant α-syn purified with either the heating or the acidification protocol, the protein was cross-linked with GHD and then analyzed by SDS-PAGE (Figure 2). After cross-linking, a smallpopulation of α-syn was found as dimers (3-5% of total α-syn) with an apparent molecular mass of ~34 kDa, as determined using the Totallab software (Figures 2A and 2B). These species were also revealed by western blot using the monoclonal antibody anti-human α-syn 14H2L1. We also observed a very small population of α-syn running at ~60 kDa. Because α-syn monomers and dimers exhibit respective molecular masses of 18 and 34 kDa according to SDS-PAGE, this 60 kDa protein may be either a tetrameric or trimeric form of α-syn.\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2013/08/04 |
| Update date | 2019/02/08 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | 2 |
| Stoichiometry for interactor B | 0 |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |