Curation Details
Interaction ID: IM-20959-3

Unique identifier for interactor Auniprotkb:P04578
Unique identifier for interactor Buniprotkb:P04608
Alternative identifier for interactor Aintact:EBI-6163496
uniprotkb:O09779
Alternative identifier for interactor Bintact:EBI-6164389
uniprotkb:O09778
Aliases for Apsi-mi:env_hv1h2(display_long)
uniprotkb:env(gene name)
psi-mi:env(display_short)
uniprotkb:Env polyprotein(gene name synonym)
Aliases for Bpsi-mi:tat_hv1h2(display_long)
uniprotkb:tat(gene name)
psi-mi:tat(display_short)
uniprotkb:Transactivating regulatory protein(gene name synonym)
Interaction detection methodspsi-mi:"MI:0096"(pull down)
First authorCardaci et al. (2013)
Identifier of the publicationpubmed:23916815
imex:IM-20959
NCBI Taxonomy identifier for interactor Ataxid:11706(hv1h2)
taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")
NCBI Taxonomy identifier for interactor Btaxid:11706(hv1h2)
taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-6899521
imex:IM-20959-3
Confidence scoreintact-miscore:0.40
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f3
comment:"\"This assay showed that Tat binding to both V1- and V2-gp120 was as low as ~30%, compared to wild-type gp120. Remarkably, V1/V2-gp120 was almost completely unable to interact with Tat (Figure 3B)\""
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2013/07/22
Update date2024/11/30
negative Boolean valuefalse
Feature(s) for interactor Amutation increasing interaction:168-168
polyprotein fragment:33-511
necessary binding region:159-194,133-155
Feature(s) for interactor Bglutathione s tranferase tag:?-?
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot