Curation Details
Interaction ID: IM-11058-1

Unique identifier for interactor Auniprotkb:Q9QWY8
Unique identifier for interactor Buniprotkb:P84080
Alternative identifier for interactor Aintact:EBI-698498
uniprotkb:Q99LV8
uniprotkb:Q9Z2B6
uniprotkb:O08612
uniprotkb:Q80TG8
uniprotkb:Q80UV6
uniprotkb:Q505F0
ensembl:ENSMUSP00000134825.2
Alternative identifier for interactor Bintact:EBI-449051
uniprotkb:A5D7F1
uniprotkb:P10947
uniprotkb:P32889
uniprotkb:Q3SZG1
ensembl:ENSBTAP00000010159.4
Aliases for Apsi-mi:asap1_mouse(display_long)
uniprotkb:PIP2-dependent ARF1 GAP(gene name synonym)
uniprotkb:ADP-ribosylation factor-directed GTPase-activating protein 1(gene name synonym)
uniprotkb:Development and differentiation-enhancing factor 1(gene name synonym)
uniprotkb:Asap1(gene name)
psi-mi:Asap1(display_short)
uniprotkb:Ddef1(gene name synonym)
uniprotkb:Kiaa1249(gene name synonym)
uniprotkb:Shag1(gene name synonym)
uniprotkb:130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein(gene name synonym)
Aliases for Bpsi-mi:arf1_bovin(display_long)
uniprotkb:ARF1(gene name)
psi-mi:ARF1(display_short)
Interaction detection methodspsi-mi:"MI:0027"(cosedimentation)
First authorKlein et al. (2005)
Identifier of the publicationpubmed:16223492
mint:MINT-5218002
imex:IM-11058
NCBI Taxonomy identifier for interactor Ataxid:10090(mouse)
taxid:10090(Mus musculus)
NCBI Taxonomy identifier for interactor Btaxid:9913(bovin)
taxid:9913("Bos taurus (Bovine)")
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-698541
imex:IM-11058-1
Confidence scoreintact-miscore:0.56
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactioncomment:"\"liposome sedimentation: only 27% of myr-Arf1 GDP and 34% of ASAP1 PZA fragment were recovered in the pelleted membrane fraction if alone. The addition of AlFx did not change the sedimentation properties of each proteins. When mixed together in presence of AlFx, both PZA and and myr-Arf1 translocated to membrane fraction within the same proportion 74% and 83% respectively.\""
stimulant:"\"AlFx (Aluminum fluoride) stabilize the complex formation between Arf1-GDP and PZA fragment of ASAP1 by mimicking activated form of Arf1, Arf1-GDP-AlFx.\""
comment:Both proteins are purified to homogeneity. Myristoylated Arf1 was produced by co-expressing in E. coli the yeast N-myristoyl-transferase.
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2005/10/17
Update date2025/07/17
negative Boolean valuefalse
Feature(s) for interactor Asufficient binding region:325-724
his tag:n-n
Feature(s) for interactor BN-myristoylglycine:2-2
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BPredetermined participant