Curation Details
Interaction ID: IM-10821-2

Unique identifier for interactor Auniprotkb:P54252-1
Unique identifier for interactor Buniprotkb:P55072
Alternative identifier for interactor Aintact:EBI-946068
ensembl:ENSP00000437157.1
Alternative identifier for interactor Bintact:EBI-355164
uniprotkb:Q9UCD5
uniprotkb:B2R5T8
uniprotkb:Q0V924
uniprotkb:Q2TAI5
intact:EBI-1046421
ensembl:ENSP00000351777.6
uniprotkb:Q969G7
intact:EBI-10175326
uniprotkb:V9HW80
Aliases for Apsi-mi:p54252-1(display_long)
uniprotkb:ATXN3(gene name)
psi-mi:ATXN3(display_short)
uniprotkb:ATX3(gene name synonym)
uniprotkb:MJD(gene name synonym)
uniprotkb:MJD1(gene name synonym)
uniprotkb:SCA3(gene name synonym)
uniprotkb:Machado-Joseph disease protein 1(gene name synonym)
uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)
uniprotkb:MJD1a(isoform synonym)
Aliases for Bpsi-mi:tera_human(display_long)
uniprotkb:VCP(gene name)
psi-mi:VCP(display_short)
uniprotkb:HEL-220(gene name synonym)
uniprotkb:HEL-S-70(gene name synonym)
uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)
uniprotkb:Valosin-containing protein(gene name synonym)
Interaction detection methodspsi-mi:"MI:0096"(pull down)
First authorBoeddrich et al. (2006)
Identifier of the publicationpubmed:16525503
mint:MINT-5218414
imex:IM-10821
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-1784532
imex:IM-10821-2
Confidence scoreintact-miscore:0.83
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:1C, 3A, 3E, 3F, 4D, S1
comment:SCA3 patients have an internal CAG repeat expansion to give 70 gln residues.
caution:The origins of the ATX43Q is however not known.
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2006/07/26
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Amutation disrupting interaction:282-282,284-284,283-283,285-285
sufficient binding region:257-291
glutathione s tranferase tag:?-?
binding-associated region:?-?
binding-associated region:?-?
Feature(s) for interactor Bhis tag:?-?
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot