Curation Details
Interaction ID: IM-10782-3

Unique identifier for interactor Auniprotkb:Q9QXM1
Unique identifier for interactor Buniprotkb:Q00987
Alternative identifier for interactor Aintact:EBI-866001
uniprotkb:Q3UQZ0
uniprotkb:Q6NST0
uniprotkb:Q8CBP9
uniprotkb:Q8VDZ3
uniprotkb:Q5BL16
Alternative identifier for interactor Bintact:EBI-389668
intact:EBI-28980679
uniprotkb:A6NL51
uniprotkb:Q13226
uniprotkb:Q13297
uniprotkb:Q13298
uniprotkb:Q13299
uniprotkb:Q13300
uniprotkb:Q13301
uniprotkb:Q53XW0
uniprotkb:Q71TW9
uniprotkb:Q8WYJ1
uniprotkb:Q8WYJ2
uniprotkb:Q9UGI3
uniprotkb:Q9UMT8
uniprotkb:A8K2S6
ensembl:ENSP00000444430.2
Aliases for Apsi-mi:jmy_mouse(display_long)
uniprotkb:Jmy(gene name)
psi-mi:Jmy(display_short)
Aliases for Bpsi-mi:mdm2_human(display_long)
uniprotkb:MDM2(gene name)
psi-mi:MDM2(display_short)
uniprotkb:p53-binding protein Mdm2(gene name synonym)
uniprotkb:Oncoprotein Mdm2(gene name synonym)
uniprotkb:Double minute 2 protein(gene name synonym)
uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)
Interaction detection methodspsi-mi:"MI:0006"(anti bait coimmunoprecipitation)
First authorCoutts et al. (2007)
Identifier of the publicationpubmed:17170761
imex:IM-10782
mint:MINT-5219464
NCBI Taxonomy identifier for interactor Ataxid:10090(mouse)
taxid:10090(Mus musculus)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-1387173
imex:IM-10782-3
Confidence scoreintact-miscore:0.40
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:5d
comment:MDM2 mutant cys462ala has no effect on interaction. Deleting region 58-89 of MDM2 decreases interaction strength.
dataset:Cancer - Interactions investigated in the context of cancer
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9606(human-u2os)
taxid:9606(Homo sapiens U2OS osteosarcoma cell)
Parameters of the interaction-
Creation date2007/01/19
Update date2024/11/14
negative Boolean valuefalse
Feature(s) for interactor Asufficient binding region:441-491
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AIdentification by antibody
Participant identification method for interactor BIdentification by antibody