Curation Details
Interaction ID: IM-10779-10

Unique identifier for interactor Auniprotkb:Q9BUJ2
Unique identifier for interactor Buniprotkb:P04637
Alternative identifier for interactor Aintact:EBI-1018153
intact:EBI-2339292
uniprotkb:B3KMW7
ensembl:ENSP00000375863.2
intact:EBI-2563529
uniprotkb:O76022
uniprotkb:Q6ZSZ0
uniprotkb:Q7L8P4
uniprotkb:Q8N6Z4
uniprotkb:Q96G37
uniprotkb:Q9HAL3
uniprotkb:Q9UG75
intact:EBI-3183399
Alternative identifier for interactor Bintact:EBI-366083
uniprotkb:Q2XN98
uniprotkb:Q3LRW1
uniprotkb:Q3LRW2
uniprotkb:Q3LRW3
uniprotkb:Q3LRW4
uniprotkb:Q3LRW5
uniprotkb:Q15086
uniprotkb:Q15087
uniprotkb:Q15088
uniprotkb:Q16535
uniprotkb:Q16807
uniprotkb:Q16808
uniprotkb:Q16809
uniprotkb:Q16810
uniprotkb:Q16811
uniprotkb:Q16848
uniprotkb:Q86UG1
uniprotkb:Q8J016
uniprotkb:Q99659
uniprotkb:Q9BTM4
uniprotkb:Q9HAQ8
uniprotkb:Q9NP68
uniprotkb:Q9NPJ2
uniprotkb:Q9NZD0
uniprotkb:Q9UBI2
uniprotkb:Q9UQ61
ensembl:ENSP00000269305.4
ensembl:ENSP00000391478.2
ensembl:ENSP00000424104.2
ensembl:ENSP00000426252.2
intact:EBI-28980681
Aliases for Apsi-mi:hnrl1_human(display_long)
uniprotkb:E1BAP5(gene name synonym)
uniprotkb:HNRNPUL1(gene name)
psi-mi:HNRNPUL1(display_short)
uniprotkb:HNRPUL1(gene name synonym)
uniprotkb:Adenovirus early region 1B-associated protein 5(gene name synonym)
uniprotkb:E1B-55 kDa-associated protein 5(gene name synonym)
Aliases for Bpsi-mi:p53_human(display_long)
uniprotkb:TP53(gene name)
psi-mi:TP53(display_short)
uniprotkb:P53(gene name synonym)
uniprotkb:Tumor suppressor p53(gene name synonym)
uniprotkb:Phosphoprotein p53(gene name synonym)
uniprotkb:Antigen NY-CO-13(gene name synonym)
Interaction detection methodspsi-mi:"MI:0096"(pull down)
First authorBarral et al. (2005)
Identifier of the publicationpubmed:15907477
imex:IM-10779
mint:MINT-5217741
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-1545897
imex:IM-10779-10
Confidence scoreintact-miscore:0.70
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:3
comment:"\"Interaction can be seen with the C-terminal and central regions and to a somewhat lesser extent with the N-terminal region. (Densitometric scanning of the autoradiograph indicates that 8%, 2%, 9% and 5% of the input of full length, N-terminal fragment, central fragment and C-terminal fragment, respectively, bound to the GST-p53.) The C-terminal and central region polypeptides of E1B-AP5 overlap from amino acids 395-732 and it is possible that these residues encompass a major binding site for p53.\""
dataset:Cancer - Interactions investigated in the context of cancer
dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2005/06/16
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor A35s radiolabel:?-?
sufficient binding region:1-453
sufficient binding region:213-732
sufficient binding region:395-856
Feature(s) for interactor Bglutathione s tranferase tag:?-?
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AMolecular weight estimation by autoradiography
Participant identification method for interactor BMolecular weight estimation by autoradiography